Similarity values obtained by G-SESAME
| | ASP3-1 | ASP3-2 | ASP3-3 | ASP3-4 | ASP1 | AAT1 | AAT2 |
| ASP3-1 | | 1 | 1 | 1 | 1 | 0.199 | 0.199 |
| ASP3-2 | | | 1 | 1 | 1 | 0.199 | 0.199 |
| ASP3-3 | | | | 1 | 1 | 0.199 | 0.199 |
| ASP3-4 | | | | | 1 | 0.199 | 0.199 |
| ASP1 | | | | | | 0.199 | 0.199 |
| AAT1 | | | | | | | 1 |
| AAT2 | | | | | | | |
Clustering results obtained by G-SESAME
| Threshold | Initial | 1.000 | 0.190 |
Clustering
Result |
|
ASP1
ASP3-4
ASP3-3
ASP3-2
ASP3-1
|
|
ASP1
ASP3-4
ASP3-3
ASP3-2
ASP3-1
AAT2
AAT1
|
|
Similarity values obtained by Resnik's method
| | ASP3-1 | ASP3-2 | ASP3-3 | ASP3-4 | ASP1 | AAT1 | AAT2 |
| ASP3-1 | | 5.904 | 5.904 | 5.904 | 5.904 | 0.281 | 0.281 |
| ASP3-2 | | | 5.904 | 5.904 | 5.904 | 0.281 | 0.281 |
| ASP3-3 | | | | 5.904 | 5.904 | 0.281 | 0.281 |
| ASP3-4 | | | | | 5.904 | 0.281 | 0.281 |
| ASP1 | | | | | | 0.281 | 0.281 |
| AAT1 | | | | | | | 6.059 |
| AAT2 | | | | | | | |
Clustering results obtained by Resnik's method
| Threshold | Initial | 6.060 | 5.860 | 0.260 |
Clustering
Result |
|
|
ASP1
ASP3-4
ASP3-3
ASP3-2
ASP3-1
|
|
ASP1
ASP3-4
ASP3-3
ASP3-2
ASP3-1
AAT2
AAT1
|
|
Analysis:
In the SGD database, genes AAT1 and AAT2 are annotated by the same molecular function term GO:0004069: aspartate
transaminase activity. ASP1, ASP3-1, ASP3-2, ASP3-3, and ASP3-4 are annotated by the same molecular function term
GO:0004067: asparaginase activity. Therefore, AAT1 and AAT2 should have the same molecular function. ASP1, ASP3-1,
ASP3-2, ASP3-3, and ASP3-4 should have the same molecular function.
Based on G-SESAME's measurement, the similarity value between AAT1 and AAT2 is 1. The similarity value among ASP1,
ASP3-1, ASP3-2, ASP3-3, and ASP3-4 also equals to 1. These results are consistent with the human perception.
However, based on Resnik's method, the similarity value between AAT1 and AAT2 is greater than the
similarity value among ASP1, ASP3-1, ASP3-2, ASP3-3, and ASP3-4, inconsistent with human perspectives.
Conclusion:
G-SESAME is better.