Similarity values obtained by G-SESAME
| | PYC1 | PYC2 | AAT1 | AAT2 |
| PYC1 | | 1 | 0.235 | 0.235 |
| PYC2 | | | 0.235 | 0.235 |
| AAT1 | | | | 1 |
| AAT2 | | | | |
Clustering results obtained by G-SESAME
| Threshold | Initial | 1.000 | 0.230 |
Clustering
Result |
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Similarity values obtained by Resnik's method
| | PYC1 | PYC2 | AAT1 | AAT2 |
| PYC1 | | 7.392 | 0.281 | 0.281 |
| PYC2 | | | 0.281 | 0.281 |
| AAT1 | | | | 6.059 |
| AAT2 | | | | |
Clustering results obtained by Resnik's method
| Threshold | Initial | 7.392 | 5.992 | 0.192 |
Clustering
Result |
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Analysis:
In the SGD database, genes AAT1 and AAT2 are annotated by the same molecular function term GO:0004069:
aspartate transaminase activity. PYC1 and PYC2
are annotated by the same molecular function term GO:0004736: pyruvate carboxylase activity.
Therefore, AAT1 and AAT2 should have the same molecular function. PYC1 and PYC2 should have the same molecular function.
Based on G-SESAME's measurement, the similarity value between AAT1 and AAT2 is 1. The similarity value between PYC1 and PYC2 also equals to 1.
These results are consistent with the human perception.
However, based on Resnik's method, the similarity value between PYC1 and PYC2 is greater
than the similarity value between AAT1 and AAT2, inconsistent with human perspectives.
Conclusion:
G-SESAME is better.