Evaluation Results

Similarity values obtained by G-SESAME

	URA1	URA2	URA3	URA4	URA5	URA6	URA7	URA8	URA10
URA1		0.227	0.235	0.235	0.235	0.185	0.274	0.274	0.235
URA2			0.193	0.193	0.285	0.220	0.439	0.439	0.285
URA3				0.199	0.199	0.154	0.235	0.235	0.199
URA4					0.199	0.154	0.235	0.235	0.199
URA5						0.260	0.235	0.235	1
URA6							0.185	0.185	0.260
URA7								1	0.235
URA8									0.235
URA10

Clustering results obtained by G-SESAME

Threshold

Initial

1.000

0.430

0.280

0.270

0.260

0.230

Clustering
Result

URA8

URA7

URA2

URA10

URA5

URA1

URA6

URA4

URA3

URA8
URA7

URA2

URA10
URA5

URA1

URA6

URA4

URA3

URA8
URA7
URA2

URA10
URA5

URA1

URA6

URA4

URA3

URA8
URA7
URA2
URA10
URA5

URA1

URA6

URA4

URA3

URA8
URA7
URA2
URA10
URA5
URA1

URA6

URA4

URA3

URA8
URA7
URA2
URA10
URA5
URA1
URA6

URA4

URA3

URA8
URA7
URA2
URA10
URA5
URA1
URA6
URA4
URA3

Similarity values obtained by Resnik's method

	URA1	URA2	URA3	URA4	URA5	URA6	URA7	URA8	URA10
URA1		0.281	0.281	0.281	0.281	0.281	0.281	0.281	0.281
URA2			0.281	0.281	1.013	1.013	2.979	2.979	1.013
URA3				0.281	0.281	0.281	0.281	0.281	0.281
URA4					0.281	0.281	0.281	0.281	0.281
URA5						1.378	0.281	0.281	6.074
URA6							0.281	0.281	1.378
URA7								4.929	0.281
URA8									0.281
URA10

Clustering results obtained by Resnik's method

Threshold

Initial

6.075

4.875

2.975

1.375

0.975

0.275

Clustering
Result

URA10

URA5

URA6

URA8

URA7

URA2

URA4

URA3

URA1

URA10
URA5

URA6

URA8

URA7

URA2

URA4

URA3

URA1

URA10
URA5

URA6

URA8
URA7

URA2

URA4

URA3

URA1

URA10
URA5

URA6

URA8
URA7
URA2

URA4

URA3

URA1

URA10
URA5
URA6

URA8
URA7
URA2

URA4

URA3

URA1

URA10
URA5
URA6
URA8
URA7
URA2

URA4

URA3

URA1

URA10
URA5
URA6
URA8
URA7
URA2
URA4
URA3
URA1

Analysis:

In SGD database, genes URA5 and URA10 are both annotated by molecular function term GO:0004588: orotate phosphoribosyltransferase activity. Genes URA7 and URA8 are annotated by the same molecular function term GO:0003883: CTP synthase activity. Therefore, URA5 and URA10 have the same molecular function, and URA7 and URA8 have the same molecular function.

G-SESAME's measurement shows the similarity between URA7 and URA8 is 1 and the similarity between URA5 and URA10 is 1, consistent with the human perception.

However, based on Resnik's method, the similarity between URA5 and URA10 is greater than the similarity between URA7 and URA8.

Conclusion:

G-SESAME is better.