Similarity values obtained by G-SESAME
| | FOL3 | DFR1 | MIS1 | ADE3 | SHM1 | SHM2 | CDC21 |
| FOL3 | | 0.199 | 0.388 | 0.388 | 0.199 | 0.199 | 0.173 |
| DFR1 | | | 0.419 | 0.419 | 0.199 | 0.199 | 0.173 |
| MIS1 | | | | 1 | 0.204 | 0.204 | 0.177 |
| ADE3 | | | | | 0.204 | 0.204 | 0.177 |
| SHM1 | | | | | | 1 | 0.633 |
| SHM2 | | | | | | | 0.633 |
| CDC21 | | | | | | | |
Clustering results obtained by G-SESAME
| Threshold | Initial | 1.000 | 0.630 | 0.410 | 0.380 | 0.200 |
Clustering
Result |
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ADE3
MIS1
DFR1
FOL3
SHM2
SHM1
CDC21
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Similarity values obtained by Resnik's method
| | FOL3 | DFR1 | MIS1 | ADE3 | SHM1 | SHM2 | CDC21 |
| FOL3 | | 0.281 | 2.305 | 2.305 | 0.281 | 0.281 | 0.281 |
| DFR1 | | | 3.409 | 3.409 | 0.281 | 0.281 | 0.281 |
| MIS1 | | | | 6.953 | 0.281 | 0.281 | 0.281 |
| ADE3 | | | | | 0.281 | 0.281 | 0.281 |
| SHM1 | | | | | | 4.977 | 4.942 |
| SHM2 | | | | | | | 4.942 |
| CDC21 | | | | | | | |
Clustering results obtained by Resnik's method
| Threshold | Initial | 6.954 | 4.954 | 4.854 | 3.354 | 2.254 | 0.254 |
Clustering
Result |
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ADE3
MIS1
DFR1
FOL3
SHM2
SHM1
CDC21
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Analysis:
Genes ADE3 and MIS1 are both annotated by three molecular function terms:
GO:0004329: formate-tetrahydrofolate ligase activity, GO:0004477: methenyltetrahydrofolate cyclohydrolase activity, and
GO:0004488: methylenetetrahydrofolate dehydrogenase (NADP+) activity.
Genes SHM1 and SHM2 are annotated by the same molecular function term GO:0004372: glycine hydroxymethyltransferase activity.
Therefore, ADE3 and MIS1 have the same molecular functions.
SHM1 and SHM2 have the same molecular function.
The similarity values and clustering results obtained by G-SESAME are consistent with these observations.
However,based on Resnik's method, the similarity between ADE3 and MIS1 is greater than the similarity between SHM1 and SHM2.
This is inconsistent with the human perception.
Conclusion:
G-SESAME is better.