35. glucose 1-phosphate metabolism

Similarity values obtained by G-SESAME

Clustering results obtained by G-SESAME

Similarity values obtained by Resnik's method

Clustering results obtained by Resnik's method

Annotation information for UGP1 and YHL012W:

Red terms annotate gene UGP1 and the green term annotates gene YHL012W.

Analysis:

The pathway annotation shows that genes UGP1 and YHL012W are both annotated with the same EC number 2.7.7.9. Therefore, it is obvious that these two genes have similarity in their molecular functions. This fact is also shown in the above gene annotation information for UGP1 and YHL012W. UGP1 is annotated by term GO:003984: UTP:glucose-1-phosphate uridylyltransferase activity, which is a descendant of term GO:0003674, which annotates gene YHL012W. However, Resnik's method indicates that YHL012W has no similarity with gene UGP1, inconsistent with the annotation information.

Conclusion:

G-SESAME is better.