Similarity values obtained by G-SESAME
| | GCV2 | GCV1 | ADE3 | MTD1 | MIS1 |
| GCV2 | | 1 | 0.249 | 0.294 | 0.249 |
| GCV1 | | | 0.249 | 0.294 | 0.249 |
| ADE3 | | | | 0.462 | 1 |
| MTD1 | | | | | 0.462 |
| MIS1 | | | | | |
Clustering results obtained by G-SESAME
| Threshold | Initial | 1.000 | 0.460 | 0.290 |
Clustering
Result |
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Similarity values obtained by Resnik's method
| | GCV2 | GCV1 | ADE3 | MTD1 | MIS1 |
| GCV2 | | 8.462 | 0.830 | 1.378 | 0.830 |
| GCV1 | | | 0.830 | 1.378 | 0.830 |
| ADE3 | | | | 3.610 | 6.953 |
| MTD1 | | | | | 3.610 |
| MIS1 | | | | | |
Clustering results obtained by Resnik's method
| Threshold | Initial | 8.463 | 6.863 | 3.563 | 1.363 |
Clustering
Result |
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Analysis:
Genes ADE3 and MIS1 are both annotated by three molecular function terms:
GO:0004329: formate-tetrahydrofolate ligase activity, GO:0004477: methenyltetrahydrofolate cyclohydrolase activity, and
GO:0004488: methylenetetrahydrofolate dehydrogenase (NADP+) activity.
GCV1 and GCV2 are annotated by the same molecular function term GO:0004375: glycine dehydrogenase (decarboxylating) activity.
Therefore, ADE3 and MIS1 have the same molecular function.
GCV1 and GCV2 have the same molecular function.
The similarity values and clustering results obtained by G-SESAME are consistent with these observations.
However,based on Resnik's method, the similarity between GCV1 and GCV2 is greater than the similarity between ADE3 and MIS1.
This is inconsistent with the human perception.
Conclusion:
G-SESAME is better.