G-SESAME is a set of on-line tools to measure the semantic similarities of Gene Ontology (GO) terms and the functional similarities of gene products, and to discover biomedical knowledge through GO database. These tools are originally based on the G-SESAME paper in 2007. They were developed using MySQL, PHP and hosted by an Apache Web server running on a Linux operating system (CentOS 5). New methods taking into account the statistical distribution of the GO database are implemented as a new feature in 2013. Other state-of-the-art methods were also implemented to allow researchers to choose the best methods on their own needs.
Visualization techniques are provided in these tools to allow users to inspect the locations of the GO terms within the GO graph and to visually determine the semantic similarity. A batch command interface is also provided for users to execute the tools to measure the semantic similarity of a group of GO terms or functional similarities of a group of genes. Web based APIs are also provided for advanced users.
G-SESAME tools have been used more than 70.2 million times by researchers from 252 organizations between October 2006 and October 2015 according to our web log recordes . G-SESAME is currently using the gene ontology database published by the gene ontology consortium in Sep, 2015 .
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This project is supported by NSF grant DBI-0960586 and DBI-0960443.